Genomic Fold Assignment and Rational Modeling of Proteins of Biological Interest

Proceedings of the Twentieth International Conference on Machine Learning, 2000

Volume

Proceedings of the Twentieth International Conference on Machine Learning, 2000

Contents

The first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling and interpretation of experimental mutagenesis data in the context of collaboration with biologists. Similar results are demonstrated for human disease proteins with known polymorphisms.