In this paper, we present a motion planning framework for a fully deployed autonomous unmanned aerial vehicle which integrates two sample-based motion planning techniques, Probabilistic Roadmaps and Rapidly Exploring Random Trees. Additionally, we incorporate dynamic reconfigurability into the framework by integrating the motion planners with the control kernel of the UAV in a novel manner with little modification to the original algorithms. The framework has been verified through simulation and in actual flight. Empirical results show that these techniques used with such a framework offer a surprisingly efficient method for dynamically reconfiguring a motion plan based on unforeseen contingencies which may arise during the execution of a plan. The framework is generic and can be used for additional platforms.