This case study concerns the use of software agent advisors to improve efficiency and quality in issue tracking activities of development teams at the world’s largest medical device manufacturer. Each software agent monitors, interacts with, and learns from its environment and user, recognizing when and how to provide different kinds of advice and support to facilitate issue tracking activities without directly modifying anything or otherwise violating domain constraints. The deployed software agent has not only enjoyed regular and growing use, but contributed to significant improvements. Issue rejection was significantly reduced and more focused, yielding significant quality and efficiency gains such as fewer reviews by quality assurance. This success reflects the benefits of the underlying AI technology.