We study the robustness of active learning (AL) algorithms against prior misspecification: whether an algorithm achieves similar performance using a perturbed prior as compared to using the true prior. In both the average and worst cases of the maximum coverage setting, we prove that all alpha-approximate algorithms are robust (i.e., near alpha-approximate) if the utility is Lipschitz continuous in the prior. We further show that robustness may not be achieved if the utility is non-Lipschitz. This suggests we should use a Lipschitz utility for AL if robustness is required. For the minimum cost setting, we can also obtain a robustness result for approximate AL algorithms. Our results imply that many commonly used AL algorithms are robust against perturbed priors. We then propose the use of a mixture prior to alleviate the problem of prior misspecification. We analyze the robustness of the uniform mixture prior and show experimentally that it performs reasonably well in practice.