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Home / Proceedings / Proceedings of the AAAI Conference on Artificial Intelligence / EAAI-20

Separating Wheat from Chaff: Joining Biomedical Knowledge and Patient Data for Repurposing Medications

February 1, 2023

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Authors

Galia Nordon

Technion-Israel Institute of Technology


Gideon Koren

Maccabi-Kahn Institute of Research and Innovation


Varda Shalev

Maccabi-Kahn Institute of Research and Innovation


Eric Horvitz

Microsoft Research


Kira Radinsky

Technion-Israel Institute of Technology


DOI:

10.1609/aaai.v33i01.33019565


Abstract:

We present a system that jointly harnesses large-scale electronic health records data and a concept graph mined from the medical literature to guide drug repurposing—the process of applying known drugs in new ways to treat diseases. Our study is unique in methods and scope, per the scale of the concept graph and the quantity of data. We harness 10 years of nation-wide medical records of more than 1.5 million people and extract medical knowledge from all of PubMed, the world’s largest corpus of online biomedical literature. We employ links on the concept graph to provide causal signals to prioritize candidate influences between medications and target diseases. We show results of the system on studies of drug repurposing for hypertension and diabetes. In both cases, we present drug families identified by the algorithm which were previously unknown. We verify the results via clinical expert opinion and by prospective clinical trials on hypertension.

Topics: AAAI

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HOW TO CITE:

Galia Nordon||Gideon Koren||Varda Shalev||Eric Horvitz||Kira Radinsky Separating Wheat from Chaff: Joining Biomedical Knowledge and Patient Data for Repurposing Medications Proceedings of the AAAI Conference on Artificial Intelligence (2019) 9565-9572.

Galia Nordon||Gideon Koren||Varda Shalev||Eric Horvitz||Kira Radinsky Separating Wheat from Chaff: Joining Biomedical Knowledge and Patient Data for Repurposing Medications AAAI 2019, 9565-9572.

Galia Nordon||Gideon Koren||Varda Shalev||Eric Horvitz||Kira Radinsky (2019). Separating Wheat from Chaff: Joining Biomedical Knowledge and Patient Data for Repurposing Medications. Proceedings of the AAAI Conference on Artificial Intelligence, 9565-9572.

Galia Nordon||Gideon Koren||Varda Shalev||Eric Horvitz||Kira Radinsky. Separating Wheat from Chaff: Joining Biomedical Knowledge and Patient Data for Repurposing Medications. Proceedings of the AAAI Conference on Artificial Intelligence 2019 p.9565-9572.

Galia Nordon||Gideon Koren||Varda Shalev||Eric Horvitz||Kira Radinsky. 2019. Separating Wheat from Chaff: Joining Biomedical Knowledge and Patient Data for Repurposing Medications. "Proceedings of the AAAI Conference on Artificial Intelligence". 9565-9572.

Galia Nordon||Gideon Koren||Varda Shalev||Eric Horvitz||Kira Radinsky. (2019) "Separating Wheat from Chaff: Joining Biomedical Knowledge and Patient Data for Repurposing Medications", Proceedings of the AAAI Conference on Artificial Intelligence, p.9565-9572

Galia Nordon||Gideon Koren||Varda Shalev||Eric Horvitz||Kira Radinsky, "Separating Wheat from Chaff: Joining Biomedical Knowledge and Patient Data for Repurposing Medications", AAAI, p.9565-9572, 2019.

Galia Nordon||Gideon Koren||Varda Shalev||Eric Horvitz||Kira Radinsky. "Separating Wheat from Chaff: Joining Biomedical Knowledge and Patient Data for Repurposing Medications". Proceedings of the AAAI Conference on Artificial Intelligence, 2019, p.9565-9572.

Galia Nordon||Gideon Koren||Varda Shalev||Eric Horvitz||Kira Radinsky. "Separating Wheat from Chaff: Joining Biomedical Knowledge and Patient Data for Repurposing Medications". Proceedings of the AAAI Conference on Artificial Intelligence, (2019): 9565-9572.

Galia Nordon||Gideon Koren||Varda Shalev||Eric Horvitz||Kira Radinsky. Separating Wheat from Chaff: Joining Biomedical Knowledge and Patient Data for Repurposing Medications. AAAI[Internet]. 2019[cited 2023]; 9565-9572.


ISSN: 2374-3468


Published by AAAI Press, Palo Alto, California USA
Copyright 2022, Association for the Advancement of
Artificial Intelligence 1900 Embarcadero Road, Suite
101, Palo Alto, California 94303 All Rights Reserved

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