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Home / Proceedings / Proceedings of the Twentieth International Conference on Machine Learning, 2000 / Book One

Towards a Systematics for Protein Subcellular Location: Quantitative Description of Protein Localization Patterns and Automated Analysis of Fluorescence Microscope Images

March 15, 2023

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Authors

Robert F. Murphy

Michael V. Boland

and Meel Velliste

Carnegie Mellon University

DOI:


Abstract:

Determination of the functions of all expressed proteins represents one of the major upcoming challenges in computational molecular biology. Since subcellular location plays a crucial role in protein function, the availability of systems that can predict location from sequence or high-throughput systems that determine location experimentally will be essential to the full characterization of expressed proteins. The development of prediction systems is currently hindered by an absence of training data that adequately captures the complexity of protein localization patterns. What is needed is a systematics for the subcellular locations of proteins. This paper describes an approach to the quantitative description of protein localization patterns using numerical features and the use of these features to develop classifiers that can recognize all major subcellular structures in fluorescence microscope images. Such classifiers provide a valuable tool for experiments aimed at determining the subcellular distributions of all expressed proteins. The features also have application in automated interpretation of imaging experiments, such as the selection of representative images or the rigorous statistical comparison of protein distributions under different experimental conditions. A key conclusion is that, at least in certain cases, these automated approaches are better able to distinguish similar protein localization patterns than human observers.

Topics: ISMB

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Robert F. Murphy||Michael V. Boland||and Meel Velliste||Carnegie Mellon University Towards a Systematics for Protein Subcellular Location: Quantitative Description of Protein Localization Patterns and Automated Analysis of Fluorescence Microscope Images Proceedings of the Twentieth International Conference on Machine Learning, 2000 (2000) .

Robert F. Murphy||Michael V. Boland||and Meel Velliste||Carnegie Mellon University Towards a Systematics for Protein Subcellular Location: Quantitative Description of Protein Localization Patterns and Automated Analysis of Fluorescence Microscope Images ISMB 2000, .

Robert F. Murphy||Michael V. Boland||and Meel Velliste||Carnegie Mellon University (2000). Towards a Systematics for Protein Subcellular Location: Quantitative Description of Protein Localization Patterns and Automated Analysis of Fluorescence Microscope Images. Proceedings of the Twentieth International Conference on Machine Learning, 2000, .

Robert F. Murphy||Michael V. Boland||and Meel Velliste||Carnegie Mellon University. Towards a Systematics for Protein Subcellular Location: Quantitative Description of Protein Localization Patterns and Automated Analysis of Fluorescence Microscope Images. Proceedings of the Twentieth International Conference on Machine Learning, 2000 2000 p..

Robert F. Murphy||Michael V. Boland||and Meel Velliste||Carnegie Mellon University. 2000. Towards a Systematics for Protein Subcellular Location: Quantitative Description of Protein Localization Patterns and Automated Analysis of Fluorescence Microscope Images. "Proceedings of the Twentieth International Conference on Machine Learning, 2000". .

Robert F. Murphy||Michael V. Boland||and Meel Velliste||Carnegie Mellon University. (2000) "Towards a Systematics for Protein Subcellular Location: Quantitative Description of Protein Localization Patterns and Automated Analysis of Fluorescence Microscope Images", Proceedings of the Twentieth International Conference on Machine Learning, 2000, p.

Robert F. Murphy||Michael V. Boland||and Meel Velliste||Carnegie Mellon University, "Towards a Systematics for Protein Subcellular Location: Quantitative Description of Protein Localization Patterns and Automated Analysis of Fluorescence Microscope Images", ISMB, p., 2000.

Robert F. Murphy||Michael V. Boland||and Meel Velliste||Carnegie Mellon University. "Towards a Systematics for Protein Subcellular Location: Quantitative Description of Protein Localization Patterns and Automated Analysis of Fluorescence Microscope Images". Proceedings of the Twentieth International Conference on Machine Learning, 2000, 2000, p..

Robert F. Murphy||Michael V. Boland||and Meel Velliste||Carnegie Mellon University. "Towards a Systematics for Protein Subcellular Location: Quantitative Description of Protein Localization Patterns and Automated Analysis of Fluorescence Microscope Images". Proceedings of the Twentieth International Conference on Machine Learning, 2000, (2000): .

Robert F. Murphy||Michael V. Boland||and Meel Velliste||Carnegie Mellon University. Towards a Systematics for Protein Subcellular Location: Quantitative Description of Protein Localization Patterns and Automated Analysis of Fluorescence Microscope Images. ISMB[Internet]. 2000[cited 2023]; .


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