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Home / Proceedings / Proceedings of the Twentieth International Conference on Machine Learning, 1995 / Book One

Periodic Sequence Patterns in Human Exons

March 15, 2023

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Authors

Pierre Baldi

Sören Brunak

Yves Chauvin

Jacob Engelbrecht

and Anders Krogh

DOI:


Abstract:

We analyse the sequential structure of human exons and their flanking introns by hidden Markov models. Together, models of donor site regions, acceptor site regions and flanked internal exons, show that exons --- besides the reading frame --- hold a specific periodic pattern. The pattern, which has the consensus: non-T(A/T)G and a minimal periodicity of roughly 10 nucleotides, is not a consequence of the nucleotide statistics in the three codon positions, nor of the well known nucleosome positioning signal. We discuss the relation between the pattern and other known sequence elements responsible for the intrinsic bending or curvature of DNA.

Topics: ISMB

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HOW TO CITE:

Pierre Baldi||Sören Brunak||Yves Chauvin||Jacob Engelbrecht||and Anders Krogh Periodic Sequence Patterns in Human Exons Proceedings of the Twentieth International Conference on Machine Learning, 1995 (1995) .

Pierre Baldi||Sören Brunak||Yves Chauvin||Jacob Engelbrecht||and Anders Krogh Periodic Sequence Patterns in Human Exons ISMB 1995, .

Pierre Baldi||Sören Brunak||Yves Chauvin||Jacob Engelbrecht||and Anders Krogh (1995). Periodic Sequence Patterns in Human Exons. Proceedings of the Twentieth International Conference on Machine Learning, 1995, .

Pierre Baldi||Sören Brunak||Yves Chauvin||Jacob Engelbrecht||and Anders Krogh. Periodic Sequence Patterns in Human Exons. Proceedings of the Twentieth International Conference on Machine Learning, 1995 1995 p..

Pierre Baldi||Sören Brunak||Yves Chauvin||Jacob Engelbrecht||and Anders Krogh. 1995. Periodic Sequence Patterns in Human Exons. "Proceedings of the Twentieth International Conference on Machine Learning, 1995". .

Pierre Baldi||Sören Brunak||Yves Chauvin||Jacob Engelbrecht||and Anders Krogh. (1995) "Periodic Sequence Patterns in Human Exons", Proceedings of the Twentieth International Conference on Machine Learning, 1995, p.

Pierre Baldi||Sören Brunak||Yves Chauvin||Jacob Engelbrecht||and Anders Krogh, "Periodic Sequence Patterns in Human Exons", ISMB, p., 1995.

Pierre Baldi||Sören Brunak||Yves Chauvin||Jacob Engelbrecht||and Anders Krogh. "Periodic Sequence Patterns in Human Exons". Proceedings of the Twentieth International Conference on Machine Learning, 1995, 1995, p..

Pierre Baldi||Sören Brunak||Yves Chauvin||Jacob Engelbrecht||and Anders Krogh. "Periodic Sequence Patterns in Human Exons". Proceedings of the Twentieth International Conference on Machine Learning, 1995, (1995): .

Pierre Baldi||Sören Brunak||Yves Chauvin||Jacob Engelbrecht||and Anders Krogh. Periodic Sequence Patterns in Human Exons. ISMB[Internet]. 1995[cited 2023]; .


ISSN:


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