Mutex propagation is a form of efficient constraint propagation popularly used in AI planning to tightly approximate the reachable states from a given state. We utilize this idea in the context of Multi-Agent Path Finding (MAPF). When adapted to MAPF, mutex propagation provides stronger constraints for conflict resolution in Conflict-Based Search (CBS), a popular optimal MAPF algorithm, and provides it with the ability to identify and reason with symmetries in MAPF. While existing work identifies a limited form of symmetries using rectangle reasoning and requires the manual design of symmetry-breaking constraints, mutex propagation is more general and allows for the automated design of symmetry-breaking constraints. Our experimental results show that CBS with mutex propagation is capable of outperforming CBSH with rectangle reasoning, a state-of-the-art variant of CBS, with respect to runtime and success rate.