In this paper we discuss possible quantum effects in the brain. We start with a historical review of what some prominent physicists have said about it. We then discuss some proposals that quantum superpositions may be used by the brain. Although decoherence effects in the brain are believed to be too strong to allow quantum computations, we describe how quantum processes support the capability of some eyes to detect small number of photons. Finally, we outline how modern physics techniques may be used to perform experiments that, if successful, would show conditioning to single photons.