Long Term Development of Toxicology Databases: The Experience Gathered By The Joint Research Centre Of The European Commission Within The ECDIN And IUCLID Projects

Flavio Argentesi and Annabelle Ascher

ECDIN (Environmental Chemicals Data Information Network) is a chemical and toxicological database covering approximately 120.000 compounds. The database includes parameters such as: nomenclature, physicochemical properties, classical toxicity, mutagenicity and carcinogenicity. This paper reviews the use of this information system in predictive toxicology during the second half of the 80’s and the early 90’s. The review highlights advantages and pitfalls of the ECDIN system for computational toxicology and permits the formulation of future developments.

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