Prevention, Detection, and Amelioration of Adverse Events in Protocol-based Decision Support

P. Hammond, A. Harris, S. Das, and J. Wyatt

The prevention, detection and amelioration of adverse events feature prominently in oncology protocols, the detailed plans for conducting clinical trials of therapies for the treatment of cancer. This paper summarises a safety review of such protocols prior to implementing OaSiS, a decision support system (DSS) in oncology [11]. Oa- SiS, shortly to undergo preliminary field evaluation in an oncology clinic, has been strongly influenced by the ONCOCIN [19], OPAL [17] and EON [16] family of computer systems developed at Stanford University in the last fourteen years. Like EON, OaSiS is a shell to be used with any oncology protocol provided it can be suitably represented. It does not support or critique the design of new protocols as do OPAL and DaT [21]. Even so, the safety review is still relevant to design tools like OPAL and DaT.

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