Proliferation of massively parallel machines have undergone the first stage where researchers learn to know what it is like. Now it come to the second stage in which researchers are asked to show visions for real applications. The author argues that Grand Challenge AI Applications should be proposed and pursued. These applications should have significant social, economic and scientific impact and serve as showcases of accomplishments of massively parallel AI. For the grand challenge to succeed, massive computing power, massive data resource, and sophisticated modeling would be critical. At the same time, it is thought that such efforts shall be promoted as international projects.