Finding Common Sequence and Structure Motifs in a set of RNA Sequences

Jan Gorodkin, Laurie J. Heyer, and Gary D. Stormo

We present a computational scheme to search for the most common motif, composed of a combination of sequence and structure constraints, among a collection of RNA sequences. The method uses a simplified version of the Sankoff algorithm for simultaneous folding and alignment of RNA sequences, but maintains tractability by constructing multi-sequence alignments from pair-wise comparisons. The overall method has similarities to both CLUSTAL and CONSENSUS, but the core algorithm assures that the pair-wise alignments are optimized for both sequence and structure conservation. Example solutions, and comparisons with other approaches, are provided. The solutions include finding consensus structures identical to published ones.


This page is copyrighted by AAAI. All rights reserved. Your use of this site constitutes acceptance of all of AAAI's terms and conditions and privacy policy.